Digestive Tract Reconstruction After Gastrectomy of Gastric Cancer With Type 2 Diabetes

Tianjin Medical University

Status: Unknown

Conditions: Gastric Cancer

Treatments: Procedure: digestive tract reconstruction

Study type: Observational

Funder types: Other

Identifiers

NCT01637350

CIH-WXN-201205001

Details and patient eligibility

About

Different digestive tract reconstruction will affect the blood glucose level of gastric cancer with type 2 diabetes. Subtotal gastrectomy with Billroth II reconstruction and total gastrectomy with Roux-en-Y reconstruction may help to improve glycaemic control which includes fasting blood glucose, postprandial blood glucose, glycosylated hemoglobin, C -peptide and body weight of gastric cancer patients with type 2 diabetes.

Full description

Different digestive tract reconstruction will affect the blood glucose level of gastric cancer with type 2 diabetes. Subtotal gastrectomy with Billroth II reconstruction and total gastrectomy with Roux-en-Y reconstruction may help to improve glycaemic control which includes fasting blood glucose, postprandial blood glucose, glycosylated hemoglobin, C -peptide and body weight of gastric cancer patients with type 2 diabetes.

The investigators will observed fasting blood glucose, postprandial blood glucose, glycosylated hemoglobin, C -peptide and body weight of the patients preoperation, 14 days postoperation 3 month and 6month postoperation. The investigators will observed the effect of blood glucose to different digestive tract reconstruction after gastrectomy of gastric cancer with type 2 diabetes

Enrollment: 60 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. 18-75 years old,gastric cancer ,can be performed operation
2. with type 2 diabetes,fasting blood glucose > 6.1mmol/L
3. without serious underlying diseases which may affect the metabolism and nutrient uptake
4. without serious underlying diseases which may affect anesthesia and operation
5. can be performed subtotal or total gastrectomy, predicted survival period > 6months
6. no other abdominal operation
7. preoperation consultation
8. informed consent

Exclusion criteria

1. recurrent,metastasis or die
2. patient requests for quit
3. pregnancy

Trial design

60 participants in 4 patient groups

Subtotal gastrectomy , BillrothⅠ

Treatment:

Procedure: digestive tract reconstruction

Subtotal gastrectomy , BillrothⅡ

Treatment:

Procedure: digestive tract reconstruction

total gastrectomy, jejunal interposition

Treatment:

Procedure: digestive tract reconstruction

total gastrectomy , Roux-en-Y

Treatment:

Procedure: digestive tract reconstruction