Digital Capillary Refill for Monitoring of Sepsis

Oregon Health & Science University (OHSU) logo

Oregon Health & Science University (OHSU)

Status

Enrolling

Conditions

Sepsis

Treatments

Device: Capillary Refill Assessment

Study type

Observational

Funder types

Other

Identifiers

NCT04529655
STUDY00021286

Details and patient eligibility

About

Observational study for monitoring of capillary refill time in sepsis

Full description

This is an observational studying assessing changes in capillary refill time over the course of sepsis treatment.

Enrollment

100 estimated patients

Sex

All

Ages

18 to 65 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Clinical evidence of a known or suspected infection and orders written for administration of IV antibiotics
  • Hypotension as defined by the need for any vasopressor (and 1 liter of fluid already administered) OR respiratory failure defined by assisted ventilation (includes mechanical ventilation and BIPAP), CPAP, or greater than or equal to 6 liters/minute of supplemental oxygen

Exclusion criteria

  • No consent/inability to obtain consent from the participant or a legally authorized representative
  • Diagnosis of cirrhosis by medical chart review
  • Liver transplant recipient
  • AST or ALT greater than five times upper limit of normal
  • Diagnosis of ongoing chronic alcohol use disorder/abuse by chart review; if medical record unclear, use Appendix F
  • Clinical diagnosis of diabetic ketoacidosis or other condition such as profound hypoglycemia that requires hourly blood glucose monitoring
  • Hypersensitivity to Acetaminophen or Vitamin C
  • Patient, surrogate or physician not committed to full support (Exception: a patient will not be excluded if he/she would receive all supportive care except for attempts at resuscitation from cardiac arrest)
  • Home assisted ventilation (via tracheotomy or noninvasive) except for CPAP/BIPAP used only for sleep-disordered breathing
  • Current active kidney stone
  • Known history of oxalate kidney stones or history of oxalate nephropathy
  • Kidney transplant recipient
  • Use of home oxygen for chronic cardiopulmonary disease
  • Moribund patient not expected to survive 24 hours
  • Underlying malignancy or other condition with estimated life expectancy of less than 1 month
  • Pregnant woman, woman of childbearing potential without a documented negative urine or serum pregnancy test during the current hospitalization, or woman who is breast feeding
  • Prisoner
  • Enrollment in another critical care based pharmacologic interventional trial
  • Treating team unwilling to enroll because of intended use of Acetaminophen or Vitamin C

Trial design

100 participants in 1 patient group

Sepsis
Description:
Patients admitted to the ICU with sepsis will be enrolled and monitored at time sequential time points during their treatment
Treatment:
Device: Capillary Refill Assessment

Trial contacts and locations

1

Loading...

Central trial contact

David Sheridan, MD

Data sourced from clinicaltrials.gov

Clinical trials

Find clinical trialsTrials by location
© Copyright 2024 Veeva Systems