Digital Therapeutics Smartphone Application for Methamphetamine Use Disorder

Adai Technology

Status: Completed

Conditions: Methamphetamine Abuse

Treatments: Behavioral: Cognitive Behavioral Therapy; Behavioral: Counseling; Behavioral: Approach Bias Modification; Behavioral: Cognitive Training

Study type: Interventional

Funder types: Other

Identifiers

NCT05550493

Feidao

Details and patient eligibility

About

One hundred participants were recruited and randomized into a digital therapeutics (DTx) group (n=52) and a treatment as usual (TAU) group (n=48). The DTx group used a smartphone application to deliver cognitive behavioral therapy, approach bias modification, cognitive training, and contingency management for eight weeks. The TAU group received counseling from social workers and psychoterapists. Cue-induced craving, cognitive functions, PHQ-9, and GAD-7 were measured at baseline and post-intervention.

Enrollment: 100 patients

Sex: All

Ages: 18 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• currently undergoing community-based rehabilitation were recruited voluntarily from four community
• meeting Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) criteria for methamphetamine dependence.

Exclusion criteria

• could not fluently operate an Android or an iOS smartphone
• having mental health conditions other than MUD

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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100 participants in 2 patient groups

Digital Therapeutics

Experimental group

Description:

The DTx group was asked to download and install a smartphone application (WonderLab Harbor) that incorporated Internet-based Cognitive Behavioral Therapy (ICBT), Approach Bias Modification (ApBM), cognitive function training, and Contingency Management (CM). During the 8-week treatment program, the participants in the DTx group were instructed to complete ICBT, cognitive trainings, and ApBM trainings. Reward points (which can be redeemed for cellphone plan credit) were rewarded following completing each task as part of the positive reinforcement following CM principles.

Treatment:

Behavioral: Cognitive Training

Behavioral: Approach Bias Modification

Behavioral: Cognitive Behavioral Therapy

Treatment as Usual

Active Comparator group

Description:

Upon enrollment, TAU participants were informed that they would receive weekly counseling sessions from a social worker for eight weeks. The counseling covered topics including work, family, stress management, and drug craving suppression.

Treatment:

Behavioral: Counseling