Dilator Muscle Activity in Health and Sleep Apnea

Bnai Zion Medical Center

Status: Unknown

Conditions: Obstructive Sleep Apnea

Treatments: Other: patients with OSA

Study type: Observational

Funder types: Other

Identifiers

NCT04254341

0096-14-BNZ

Details and patient eligibility

About

The role of control of peri-pharyngeal muscle tone in the pathogenesis of obstructive sleep apnea (OSA) is obvious: pharyngeal obstruction occurs only during sleep; and pharyngeal collapse occurs in almost all healthy subjects during anesthesia. Better understanding of these control mechanisms may help identifying the central components of the pathogenesis of OSA.

Full description

Study plan: Subjects will be studied first during wakefulness, while breathing against external resistors, to evaluate how are the peri-pharyngeal muscles recruited and activated to prevent pharyngeal collapse in the presence of negative intra-pharyngeal pressures. Thereafter, the same parameters will be evaluated during sleep, to assess muscle recruitment during intra-pharyngeal obstruction. The investigaors will record the electromyogram (EMG) of several dilator muscles, as well as the pressures above and below the area of pharyngeal collapse, and airflow.

Enrollment: 20 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. subjects that underwent regular sleep studies and found to have either moderate/severe OSA, or no OSA.

Exclusion criteria

1. hemophilia
2. use of anti-coagulants -

Trial design

20 participants in 2 patient groups

patients with OSA

Description:

Subjects that underwent regular sleep studies (PSG) and found to have moderate/severe obstructive sleep apnea

Treatment:

Other: patients with OSA

subjects without OSA

Description:

Subjects that underwent regular PSG and found not to have sleep apnea

Treatment:

Other: patients with OSA