Diphenhydramine in Catheter Related Bladder Discomfort

Cairo University (CU)

Status: Invitation-only

Conditions: Catheter Complications

Treatments: Drug: Saline; Drug: DiphenhydrAMINE 50 Mg/mL Injectable Solution

Study type: Interventional

Funder types: Other

Identifiers

NCT06345261

2024-872

Details and patient eligibility

About

Diphenhydramine has H1-antihistamine action, it also possesses anti-muscarinic properties. Thus, diphenhydramine might be able to reduce the problem of catheter related bladder discomfort by inhibiting smooth muscle spasm of the urinary bladder via its anti-muscarinic action .

Enrollment: 104 estimated patients

Sex: Male

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

male patients aged more than18-80 years ASA I and II , upper ureteric stone removal under general anesthesia r

Exclusion criteria

overactive bladder cognitive impairment a neuropsychological disorder, bladder outflow obstruction urinary tract infection, , neurogenic bladder, operative time > 6 h

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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104 participants in 2 patient groups, including a placebo group

Diphenhydramine group

Active Comparator group

Treatment:

Drug: DiphenhydrAMINE 50 Mg/mL Injectable Solution

control group

Placebo Comparator group

Treatment:

Drug: Saline