Direct Bypass Versus Indirect Bypass in Treatment of Adults Hemorrhagic Moyamoya Disease

liuxingju

Status: Unknown

Conditions: Moyamoya Disease

Treatments: Other: bypass surgery and indrect bypass surgery

Study type: Interventional

Funder types: Other

Identifiers

NCT02982135

BJTTH-003

Details and patient eligibility

About

The investigators conducted a prospective multi-center study assessing the effect of direct bypass and indrect bypass in treatment of hemorrhagic moyamoya disease.

Enrollment: 300 estimated patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. cerebral digital subtraction contrast angiography (DSA) revealed severe stenosis or occlusion of the distal internal carotid or proximal middle and anterior cerebral arteries with prominent lenticulostriate "moyamoya collaterals"
2. patients had experienced at least one intracranial hemorrhage which was verified by computed tomography (CT) scanning, magnetic resonance imaging MRI), or lumbar puncture.
3. Patients requiring surgery

Exclusion criteria

1. Patient whose initial onset was marked by ischemia but subsequently suffered from intracranial hemorrhage
2. patients refused to participate in the study

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Factorial Assignment

Masking: Single Blind

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300 participants in 2 patient groups

group 1 direct bypass

Other group

Description:

direct bypass : patients recieve direct bypass treatment

Treatment:

Other: bypass surgery and indrect bypass surgery

group 2 indirect bypass

Other group

Description:

indirect bypass: patients recieve indirect bypass treatment

Treatment:

Other: bypass surgery and indrect bypass surgery