Direct Evaluation of Postoperative Myocardial Injury Using Coronary Computed Tomography Angiography After Non-Cardiac Surgery

UMC Utrecht

Status

Unknown

Conditions

Postoperative Myocardial Injury

Treatments

Radiation: Coronary Computed Tomography Angiography

Study type

Observational

Funder types

Other

Identifiers

NCT02682966

DEPICT-NCS

Details and patient eligibility

About

This is a prospective study in patients who undergo routine postoperative troponin assessment after major (semi-)elective noncardiac surgery. Two groups are created based on postoperative troponin levels: Postoperative myocardial injury (PMI) group with troponin I levels ≥ 60 ng/L and a control group with troponin levels < 60ng/L. The primary aim of this study is to assess the association of PMI with pulmonary embolism. Additionally, the association between PMI and obstructive CAD will be investigated.

Enrollment

354 estimated patients

Sex

All

Ages

60+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

≥ 60 years old
Major noncardiac surgery, defined as non-cardiac surgical procedures requiring hospital admittance > 24 hours
Semi-elective surgery, defined as surgery that that has been preceded by a preoperative evaluation.
≥ 1 troponin assessment in the first 3 postoperative days as a part of the routine 'postoperative troponin assessment' protocol.
For patients who undergo surgery more than once, the first surgery will be included in the analysis. Reoperations will not be included.

Exclusion criteria

Typical anginal complaints
Acute ST-elevation myocardial infarction (STEMI) or new left bundle branch block (LBBB) on ECG
Patients unable to fully comply to study needs (e.g. incompetent patients or patients unable to communicate in Dutch or English)
Severe claustrophobia.
Patients who have a life expectancy of less than three months.
Patients who are too ill to undergo a CCTA or Ventilation/Perfusion (V/Q) scan.