Direct Measurement of Motor Cortical Responses to tDCS

Medical University of South Carolina (MUSC)

Status: Completed

Conditions: Parkinson Disease; Chronic Stroke

Treatments: Device: transcranial direct current stimulation (invasive recording); Device: sham transcranial direct current stimulation (noninvasive recording); Device: transcranial direct current stimulation (noninvasive recording)

Study type: Interventional

Funder types: Other

Identifiers

NCT04759898

00073545

Details and patient eligibility

About

Transcranial direct current stimulation (tDCS) has shown the potential to improve symptoms in patients with movement deficits, such as Parkinson's disease and chronic stroke. However, the effects of tDCS have so far not been proven on a wider scale due to lack of knowledge regarding exactly how tDCS works. This has limited the adoption of this potentially useful therapy for patients with Parkinson's disease, chronic stroke and other conditions affecting movement. The investigators hypothesize that by studying the effects of tDCS in subjects performing a motor task, the brain signals mediating improvements in motor control will be identified. The investigators will use both noninvasive and invasive methods to explore this hypothesis. The investigators expect this combined approach to broaden understanding of tDCS application in conditions affecting movement and possibly lead to therapeutic advances in these populations.

Enrollment: 80 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age 18 or older
• Previous consent to be contacted regarding potential participation in a research study at Medical University of South Carolina

Exclusion criteria

• Subjects unable to actively participate in the consent process physically and/or cognitively
• Pregnancy
• Presence of scalp injury or disease
• Prior history of seizures
• Metal implants in head or neck
• Prior intracranial surgery
• Prior brain radiotherapy
• Prior history of intracranial tumor, intracranial infection or cerebrovascular malformation

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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80 participants in 3 patient groups

Stimulation (noninvasive recording)

Active Comparator group

Description:

Patients with Parkinson's disease or chronic stroke will be assigned to undergo EEG recording and transcranial direct current stimulation.

Treatment:

Device: transcranial direct current stimulation (noninvasive recording)

Sham (noninvasive recording)

Sham Comparator group

Description:

Patients with Parkinson's disease or chronic stroke will be assigned to undergo EEG recording and sham transcranial direct current stimulation.

Treatment:

Device: sham transcranial direct current stimulation (noninvasive recording)

Stimulation (invasive recording)

Experimental group

Description:

Patients with Parkinson's disease undergoing surgery for deep brain stimulation will be studied using electrocorticography combined with transcranial direct current stimulation

Treatment:

Device: transcranial direct current stimulation (invasive recording)