Discontinuation of Antibiotic Susceptibility Testing on Enterococcus Faecalis Positive Urine Cultures in Hospitalized Patients: an Impact on Antibiotic Prescriptions? (FaecaCible)

Central Hospital, Nancy, France

Status: Completed

Conditions: Antibiotic Susceptibility Reporting

Treatments: Other: Stop performing an antibiotic susceptibility test

Study type: Observational

Funder types: Other

Identifiers

NCT05743192

2022PI075

Details and patient eligibility

About

The objective of the study is to evaluate the impact of not reporting antibiotic susceptibility tests on antibiotic consumption for Enterococcus faecalis positive urine cultures in adult hospitalized patients. The secondary objectives are to evaluate the impact of this intervention on antibiotic prescription rates as well as on antibiotic consumption according to: patient gender, type of antibiotic therapy (probabilistic/documented) and diagnosis (urinary tract infection or colonization). It is hypothesized that antibiotic consumption is lower after the application of the absence of antibiotic susceptibility reporting compared to before.

Enrollment: 217 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Person having received complete information on the organization of the research and not having objected to the exploitation of these data
• Adult patients (More than 18);
• Having performed a urine culture at the Nancy University Hospital, taken from the 2nd urine stream, by urinary catheter or via a suprapubic catheter and whose culture is positive for monomicrobial E. faecalis with a bacteriuria threshold greater than or equal to 10^3 CFU/field;
• Hospitalized at the Nancy University Hospital at least 72 hours after validation of the antibiotic susceptibility test in the pre-intervention period and at least 72 hours after validation of the culture in the post-intervention period.

Exclusion criteria

• Inpatients in hematology, critical care/intensive care, consultation and day hospital units;
• Urine cultures performed in ambulatory units ;
• Urine culture performed in the critical care/intensive care/hematology units;
• Patients discharged from hospital/deceased/transferred to intensive care within 72 hours of the validation of the antibiotic susceptibility test or the validation of the urine culture;
• Patients with associated E. faecalis bacteremia;
• Urine culture without an antibiotic susceptibility test for the pre-intervention period;
• Urine culture with a monomicrobial history of less than 1 week;
• Culture of urine from pyelic punctures or nephrostomy tubes - conservation of those from second streams, urinary catheters and suprapubic catheters).

Trial design

217 participants in 2 patient groups

Before group

Description:

Group of patients with a positive urine culture for Enterococcus faecalis before the procedure consisting of systematically performing an antibiotic susceptibility test.

After group

Description:

Group of patients with a positive urine culture for Enterococcus faecalis after the procedure consisting of systematically performing an antibiotic susceptibility test.

Treatment:

Other: Stop performing an antibiotic susceptibility test