Discontinuation Order of Vasopressors in Septic Shock (DOVSS)

Samsung Medical Center

Status

Terminated

Conditions

Septic Shock

Treatments

Drug: Norepinephrine

Drug: Vasopressin

Study type

Interventional

Funder types

Other

Identifiers

NCT01493102

2011-09-007

Details and patient eligibility

About

The purpose of this study is to evaluate the incidence of hypotension based on the discontinuation order of norepinephrine and vasopressin in patients receiving concomitant norepinephrine and vasopressin infusions for the treatment of septic shock.

Full description

There are little data regarding the discontinuation of vasopressors in patients with septic shock. Therefore, the investigators intend to evaluate the incidence of hypotension based on the discontinuation order of norepinephrine and vasopressin in patients receiving concomitant norepinephrine and vasopressin infusions for the treatment of septic shock.

Enrollment

78 patients

Sex

All

Ages

20+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

patients 20 years of age or older
patients of receiving concomitant therapy with norepinephrine and vasopressin for teh management of septic shock
patients began to reduce the vasopressor

Exclusion criteria

patients who expired or had care withdrawn while receiving norepinephrine and vasopressin
patients being transferred into the ICU from an outside facility or the operating room
patients who are suspected to have vasopressin deficiency (eg. HPA axis dysfunction, empty sella)
acute myocardial infarction or Congestive heart failure (NYHA functional classification III or IV)
acute mesenteric ischemia
patients who were received other vasopressor except for norepinephrine or vasopressin