Discovering Cancer Risks From Environmental Contaminants and Maternal/Child Health

University of California San Francisco (UCSF)

Status: Terminated

Conditions: Cancer

Treatments: Other: Specimen sample collection; Other: Health Questionnaires

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT05746169

21621

UG3CA265845 (U.S. NIH Grant/Contract)

NCI-2022-10633 (Registry Identifier)

Details and patient eligibility

About

The DREAM Cohort is a longitudinal observational study developed to enhance our understanding of how multiple exposures to environmental chemicals and pollutants across a diverse population of pregnant women and their offspring are linked to cancer risks. Because pregnancy induces multiple maternal hormonal and physiological changes that can increase cancer susceptibility to environmental chemical exposures, this study will focus on pregnancy as a period of particular vulnerability to toxic agents.

Full description

The environmental exposures will focus on two major components: Consumer product related chemicals (including per- and polyfluoroalkyl substances (PFAS), phthalates and plasticizers, phenolic compounds, pesticides, and aromatic amines) measured via biomonitoring and prioritized based on widespread public exposure; and environmental pollutants in air and water, evaluated via geographic information system analyses of participants' residential histories.

The study team will collect questionnaire data and biospecimen samples starting at the second trimester of pregnancy up until the child reaches four years of age. A Cohort Ambassador Program will also be established to invite participants across our three sites to provide continuous feedback which will be integrated into the research priorities.

Enrollment: 1,576 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Pregnant women, over the age of 18 years.
• English or Spanish-speaking.
• Children born of participants enrolled during pregnancy will be enrolled in the DREAM cohort.
• Inclusion criterion for the DREAM Cohort Ambassador Program is limited to research participants in the DREAM Cohort.

Exclusion criteria

• Women under the age of 18.
• Women expecting the birth of multiples (twins, triplets, etc.).

Trial design

1,576 participants in 1 patient group

Pregnant women and their children

Description:

The DREAM cohort will recruit from University of California, San Francisco (UCSF) Mission Bay, Zuckerberg San Francisco General Hospital, and Fresno Community Medical Center locations to enroll an economically, geographically, ethnically and racially diverse cohort of pregnant women and their children for long term follow-up.

Treatment:

Other: Health Questionnaires

Other: Specimen sample collection