Discovery for Biomarkers and Risk Factors for Postoperative Delirium in Elderly Patients With Spine Surgery

Yonsei University

Status: Unknown

Conditions: Spinal Disease

Treatments: Procedure: Spine surgery

Study type: Observational

Funder types: Other

Identifiers

NCT04120272

4-2019-0654

Details and patient eligibility

About

Introduction: With the increase of the elderly population, the number of elderly patients undergoing surgery is increasing, and postoperative delirium is 11-51% depending on the type of surgery. In recent cohort studies have shown that delirium might reduce cognitive function and develop dementia.

Since delirium is difficult to treat, the key to treatment is prevention, and about 40% is prevented when prophylactic intervention is applied. However, delirium is difficult to diagnose and difficult to predict, therefore, biomarkers are needed to diagnose and prevention.

Exosome and brain efficiency test(electroencephalogram, and pulse wave test) have the potential of simple biomarkers that can diagnose postoperative delirium and predict cognitive decline.

Purpose: The purpose of this study is to investigate the risk factors affecting delirium in the elderly who have spinal surgery and to search for biomarkers of delirium for early detection and prevention of delirium.

Full description

Method:

1. Study design: This study is a prospective investigation that identifies risk factors for postoperative delirium and searches for predictive biomarkers of delirium.

2. Inclusion criteria / Exclusion Criteria

   1. Inclusion criteria

      • Elderly patients over 70
      • Eligible Surgeries: lumbar spine fusion surgery, posterior cervical spine fusion surgery, or anterior cervical spine fusion surgery

   2. Exclusion Criteria

      • Patients with cognitive decline according to MMSE-DS outcome criterion
      • Patients diagnosed with malignant or benign tumors
      • If surgery is scheduled within 2 hours(micro surgery)
      • In case of difficulty in communication
      • History of brain neurological diseases (brain hemorrhage, stroke, dementia, Parkinson's, cognitive impairment diagnosis, etc.)
      • Patients diagnosed with alcoholism or drug addiction
      • Patients with surgical complications (post-operative bleeding, high fever over 39 degrees, etc.)
      • Patients undergoing re-operation due to surgery-related complications

3. Outcome

   1. Primary outcome: Urinary and Blood exosome, stool
   2. Secondary outcome: brain function test(electroencephalogram, pulse wave test, and cognitive test)

4. Measurement

   1. Delirium: Confusion Assessment Method(CAM), Korean-Delirium Rating Scale-R-98(K-DRS-R-98), Korean Nusing Delirium Scale(Nu-DESC)
   2. Cognitive function test: Mini-Mental State Examination-Dementia Screening(MMSE-DS), Montreal Cognitive Assessment(MoCA), Telephone interview for Cognitive Status(TICS)
   3. Depression: Geriatric Depression Scale Short Form Version (GDSSF-K)
   4. Activity Daily of Living: K-ADL, K-IADL
   5. Frail: Korean version of the FRAIL scale
   6. Nutrition: Mini Nutritional Assessment-Short Form
   7. patient-reported outcomes ; PROMIS-29

Enrollment: 600 estimated patients

Sex: All

Ages: 70 to 100 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Elderly patients over 70
2. Eligible Surgeries: lumbar spine fusion surgery, posterior cervical spine fusion surgery, or anterior cervical spine fusion surgery

Exclusion criteria

1. Patients with cognitive decline according to MMSE-DS outcome criterion
2. Patients diagnosed with malignant or benign tumors
3. If surgery is scheduled within 2 hours(micro surgery)
4. In case of difficulty in communication
5. History of brain neurological diseases (brain hemorrhage, stroke, dementia, Parkinson's, cognitive impairment diagnosis, etc.)
6. Patients diagnosed with alcoholism or drug addiction
7. Patients with surgical complications (post-operative bleeding, high fever over 39 degrees, etc.)
8. Patients undergoing re-operation due to surgery-related complications

Trial design

600 participants in 2 patient groups

Delirium group

Description:

Group of patients with postoperative delirium

Treatment:

Procedure: Spine surgery

Non delirium group

Description:

Group of patients without postoperative delirium

Treatment:

Procedure: Spine surgery