Disease Risk Reduction and Omega-3 Rich Rainbow Trout (Fish for Health)

USDA Grand Forks Human Nutrition Research Center

Status: Terminated

Conditions: Obesity

Treatments: Other: 3N Trout; Other: Tilapia; Other: 2N Trout

Study type: Interventional

Funder types: Other U.S. Federal agency

Identifiers

NCT02204709

GFHNRC029

Details and patient eligibility

About

The purpose of this study is to determine how eating fish raised to have different levels of omega-3 fatty acids will reduce cardiovascular risk markers in people with elevated cardiovascular risk.

Full description

Consumption of fish high in long chain omega-3 fatty acids (LCn3) is associated with reduction of cardiovascular disease (CVD) risk. CVD is a major cause of death in the United States. The current obesity epidemic contributes significantly to elevated CVD risk by increasing inflammation and platelet dysfunction. Prevention of CVD is a public health goal and comprises several avenues of action, of which inclusion of LCn3-rich fish in the diet may be one of the most effective.

Obese participants will participate in a double blind, randomized, cross-over designed trial in which they will consume twice-weekly a prepared meal containing diploid (2N) farmed rainbow trout, triploid (3N) farmed rainbow trout containing higher levels of LCn3, or tilapia, a low LCn3 fish.

Enrollment: 29 patients

Sex: All

Ages: 20 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• BMI of 30 - 39.9 kg/m2

Exclusion criteria

• Are allergic to fish
• Use tobacco products or nicotine in any form including snuff, pills, and patches, or e-cigarettes in the past 6 months
• Have established cardiovascular, pulmonary, and/or a metabolic disease such as diabetes
• Have uncontrolled high blood pressure
• Have alcohol, anabolic steroids, or other substance abuse issues
• Consume more than 3 alcoholic drinks/week
• Have cancer
• Are pregnant or nursing
• Take non-steroidal anti-inflammatory drugs such as aspirin, ibuprofen or Aleve, lipid modifying drugs such as statins, take medications for blood glucose such as insulin or metformin

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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29 participants in 3 patient groups

Diploid Trout entrees

Experimental group

Description:

Subjects will consume a 200 gram portion of 2N trout (diploid; two sets of chromosomes) twice weekly in a prepared meal.

Treatment:

Other: 2N Trout

Triploid Trout entrees

Experimental group

Description:

Subjects will consume a 200 gram portion of 3N trout (triploid; three sets of chromosomes) twice weekly in a prepared meal.

Treatment:

Other: 3N Trout

Tilapia entrees

Experimental group

Description:

Subjects will consume a 200 gram portion of tilapia twice weekly in a prepared meal.

Treatment:

Other: Tilapia