Dispersion of Local Anesthetic on the Erector Spinae Plane Block in Cadavers

Federal University of São Paulo

Status: Unknown

Conditions: Nerve Block

Treatments: Procedure: Erector Spinae Plane Block

Study type: Interventional

Funder types: Other

Identifiers

NCT03545854

Erector Spinae Plane Block

Details and patient eligibility

About

This study aims to better understand the dispersion of local anesthetic on the Erector Spinae Block, a new technique developed for analgesia. It consists on injection of local anesthetic around the posterior muscles of the Spine. In this study, the investigators will make the injection with coloring solution on cadavers and by dissection will note the dispersion of the solution according to injectate volume. The investigators hypothesize more volume allows bigger spread and will allow new indications of this technique in perioperative analgesia and treatment of chronic Pain

Full description

The study's methodology will include performing ultrasound guided erector spinae block in cadavers included in the study according to eligibility criteria. After signing of written consent form, the participants will be randomized on the height of the block (vertebral level - T3, T12 and L4) and the volume to be injected (10, 20 and 30ml). The block will be performed by experienced physicians on the technique by ultrasound guidance and fixed pressure measured with an in-line pressure monitor (15 psi) with the cadaver in the lateral position. The cadavers will be submitted to autopsy by standard thoracoabdominal midline incision, with the viscera removed for analysis. The cadavers will have their paraspinal muscles removed (quadratus lumborum and psoas major), the medial parietal pleura opened and the number of levels with colored solution registered, noting the spread to ventral rami of spinal nerves and to the paravertebral space.

Enrollment: 20 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Fresh Cadavers (not subject to formaldehyde fixation process or frozen > 24h)
• Age > 18 years
• Written informed consent signed by responsible party
• Height > 150cm and < 190cm

Exclusion criteria

• Previous spinal surgery
• Severe spinal deformity
• BMI > 35 kg/m2
• Absence of a responsible party to sign the written informed consent

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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20 participants in 9 patient groups

T3 10ml

Experimental group

Description:

The cadaver will receive an ultrasound-guided Erector Spinae Plane Block with 10ml of coloring solution at the T3 vertebral level

Treatment:

Procedure: Erector Spinae Plane Block

T3 20ml

Experimental group

Description:

The cadaver will receive an ultrasound-guided Erector Spinae Plane Block with 20ml of coloring solution at the T3 vertebral level

Treatment:

Procedure: Erector Spinae Plane Block

T3 30ml

Experimental group

Description:

The cadaver will receive an ultrasound-guided Erector Spinae Plane Block with 30ml of coloring solution at the T3 vertebral level

Treatment:

Procedure: Erector Spinae Plane Block

T12 10ml

Experimental group

Description:

The cadaver will receive an ultrasound-guided Erector Spinae Plane Block with 10ml of coloring solution at the T12 vertebral level

Treatment:

Procedure: Erector Spinae Plane Block

T12 20ml

Experimental group

Description:

The cadaver will receive an ultrasound-guided Erector Spinae Plane Block with 20ml of coloring solution at the T12 vertebral level

Treatment:

Procedure: Erector Spinae Plane Block

T12 30ml

Experimental group

Description:

The cadaver will receive an ultrasound-guided Erector Spinae Plane Block with 30ml of coloring solution at the T12 vertebral level

Treatment:

Procedure: Erector Spinae Plane Block

L4 10ml

Experimental group

Description:

The cadaver will receive an ultrasound-guided Erector Spinae Plane Block with 10ml of coloring solution at the L4 vertebral level

Treatment:

Procedure: Erector Spinae Plane Block

L4 20ml

Experimental group

Description:

The cadaver will receive an ultrasound-guided Erector Spinae Plane Block with 20ml of coloring solution at the L4 vertebral level

Treatment:

Procedure: Erector Spinae Plane Block

L4 30ml

Experimental group

Description:

The cadaver will receive an ultrasound-guided Erector Spinae Plane Block with 30ml of coloring solution at the L4 vertebral level

Treatment:

Procedure: Erector Spinae Plane Block