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Disruption of Memory Reconsolidating as a Treatment for Panic Disorder

V

VU University of Amsterdam

Status and phase

Unknown
Phase 2

Conditions

Panic Disorder

Treatments

Other: Compressed air
Drug: Propranolol
Other: Carbon dioxide
Drug: Placebo

Study type

Interventional

Funder types

Other

Identifiers

NCT02631694
MKAEWC1

Details and patient eligibility

About

Animal and human fear conditioning studies have repeatedly shown that administering propranolol before or after retrieval of a previously acquired fear results in an elimination of the fear expression. This approach, known as disruption of fear memory reconsolidation, is a promising new avenue for treating anxiety disorders. The present study aims to test its efficacy in patients with panic disorder.

Enrollment

60 estimated patients

Sex

All

Ages

18 to 65 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • a primary diagnosis of panic disorder according to DSM-V
  • written approval of an independent physician for participation

Exclusion criteria

  • other relevant treatment for panic disorder at the time of study - e.g., Cognitive Behavioral Therapy (CBT)
  • diagnosis of depression
  • diagnosis of psychosis
  • use of psychotropic medication
  • history of pulmonary diseases
  • metabolic acidosis
  • history of cardiovascular diseases
  • heart problems among first-degree relatives
  • heart rate (HR) < 60
  • blood pressure (BP) < 90-60 or BP > 170-100
  • history of black-outs or fainting
  • diabetes
  • liver or kidney diseases
  • hyperactive production of thyroid hormones
  • epilepsy
  • any medication contra-indicative of the use of propranolol
  • pregnancy

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Triple Blind

60 participants in 3 patient groups, including a placebo group

Fear reactivation with propranolol
Experimental group
Treatment:
Drug: Propranolol
Other: Carbon dioxide
Fear reactivation with placebo
Placebo Comparator group
Treatment:
Drug: Placebo
Other: Carbon dioxide
No fear reactivation with propranolol
Placebo Comparator group
Treatment:
Other: Compressed air
Drug: Propranolol

Trial contacts and locations

0

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Central trial contact

Arnold A.P. van Emmerik, PhD

Data sourced from clinicaltrials.gov

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