Dissecting the Mechanism of DNA Methylation on the Invasiveness of Pituitary Tumors.

Zhejiang University

Status: Enrolling

Conditions: Pituitary Tumors

Treatments: Other: no interventions between two groups

Study type: Observational

Funder types: Other

Identifiers

NCT05634655

2021-0765

Details and patient eligibility

About

DNA methylation is one of the important ways of protein post-translational modification.Pituitary adenoma (PA) is a benign neuroendocrine tumor that originates from adenohypophysial 45 cells, and accounts for 10%-20% of all primary intracranial tumors. However some PAs can present with high invasiveness and irregular growth, which tend to compresses the optic chiasm and third ventricle, encase the internal carotid artery, and affect hormone secretion from the pituitary gland and hypothalamus. In this study we focus on the mechanism of DNA methylation on the invasiveness of pituitary tumors.

Enrollment: 500 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• 1. histologically confirmed PAs, 2) Non-function pituitary adenomas

Exclusion criteria

• 1. Associated with other tumors or serious underlying diseases, 2) the medical records were not complete, or the follow-up data were missing.

Trial design

500 participants in 2 patient groups

invasive PAs

Treatment:

Other: no interventions between two groups

non-invasive PAs

Treatment:

Other: no interventions between two groups