Distal Erosions and Nail Psoriasis (PSUPSO)

Civil Hospices of Lyon

Status: Unknown

Conditions: Psoriatic Arthritis

Treatments: Radiation: HR-pQCT High resolution peripheral quantitative CT-scan

Study type: Observational

Funder types: Other

Identifiers

NCT02813720

69HCL16_0202

Details and patient eligibility

About

Nearly 30% of patients with cutaneous psoriasis (PsO) developed psoriatic arthritis (PsA). Among these patients 20 % will have severe destructive arthritis. The risk of developing PsA is significantly higher in patients with nail involvement (OR = 2.24; 95% CI [1.26-3.98]). The risk is particularly high for the peripheral form of PsA and onycholysis (OR=2.80; 95% CI [1.34-5.85]).

Thus the investigators wanted to test the hypothesis that onycholysis, in patients without PsA, is a potential clinical marker of subclinical distal enthesopathy and, by extension, of bone micro-structural alterations.

Patients and Methods

The investigators will recruit 4 groups of subjects:

1. Patients with peripheral PsA,
2. Patients with psoriatic nail onycholysis,
3. Patients with PsO only
4. Healthy match control subjects. The investigators will assess the presence of enthesopathy by ultrasonography and bone structural damages (by HR-pQCT) in all subjects at baseline and 4 years.

Enrollment: 104 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• adults over 18 years and until 65 years
• both gender
• covered by the French National Insurance
• subjects entering one of the 4 groups.

Exclusion criteria

• Treatment by biological agents are an exclusion criteria for PsO, onycholysis and control patients.
• Pregnant women

Trial design

104 participants in 4 patient groups

Patients with peripheral PsA

Treatment:

Radiation: HR-pQCT High resolution peripheral quantitative CT-scan

Patients with psoriatic nail onycholysis

Treatment:

Radiation: HR-pQCT High resolution peripheral quantitative CT-scan

Patients with PsO only

Treatment:

Radiation: HR-pQCT High resolution peripheral quantitative CT-scan

Healthy match control subjects

Treatment:

Radiation: HR-pQCT High resolution peripheral quantitative CT-scan