Distribution and Analysis of Metastatic Lymph Nodes in Colorectal Cancer Patients (DIAMOND)

Chinese Academy of Medical Sciences & Peking Union Medical College

Status: Not yet enrolling

Conditions: Colon Cancer; Rectal Cancer

Study type: Observational

Funder types: Other

Identifiers

NCT07306390

25/631-5577

Details and patient eligibility

About

The goal of this observational study is to learn about the spatial distribution and significance of metastatic lymph nodes in colorectal cancer patients. The main question it aims to answer is:

• What is the spatial distribution pattern of metastatic lymph nodes in patients with colorectal cancer?
• Can the spatial distribution pattern of metastatic lymph nodes in patients with colorectal cancer guide clinical practice? Participants should undergo regular follow-up examinations for at least 5 years after the surgery.

Enrollment: 1,200 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Aged between 18 and 80 years
• Pathologically confirmed adenocarcinoma of the colon or rectum
• Underwent radical resection for colorectal cancer with a D3 lymphadenectomy and lymph nodes were submitted for pathological examination according to standardized station-based and distance-based protocol
• No distant metastasis or distant metastasis within 6 months after surgery
• No history of other malignant tumors or severe systemic diseases
• No immune diseases or inflammatory bowel diseases
• Non-emergency surgery
• With complete clinicopathological and follow-up data

Exclusion criteria

• Pathologically confirmed benign tumors or non-adenocarcinoma malignancies
• Underwent local excision or palliative resection
• Regional lymph nodes were not dissected or submitted for pathological examination according to the unified station-based or distance-based protocol
• With distant metastasis or distant metastasis within 6 months after surgery
• Dual or multiple primary colorectal cancers or concurrent other malignant tumors
• Had a previous diagnosis of immune diseases or inflammatory bowel disease such as ulcerative colitis or Crohn's disease
• Underwent emergency surgery
• Had incomplete clinicopathological or follow-up data

Trial design

1,200 participants in 1 patient group

Colorectal Cancer Patients