Distribution and Prognostic Impact of Oncogenic Drivers in Metastatic Lung Adenocarcinoma : a Retrospective Monocentric Study in Nancy University Hospital Center

Central Hospital, Nancy, France

Status: Completed

Conditions: Adenocarcinoma of Lung, Response to Tyrosine Kinase Inhibitor in, Somatic; Adenocarcinoma of Lung Stage IV

Study type: Observational

Funder types: Other

Identifiers

NCT04493827

2019PI224

Details and patient eligibility

About

The recent discovery of oncogenic drivers has revolutionized the management of advanced lung cancer by development of tyrosine kinase inhibitors targeted therapies. Prevalence of daily tobacco use is evaluated at 31,3 % in Grand-Est region, the only French region with a statistically significative difference for smoking habits. This region shows a higher incidence (+ 13 %) and mortality for lung cancer in comparison to the average for other French regions. The objectives of our studie were to estimate the distribution of oncogenic drivers and analyse their prognostic impacts in the Nancy University Hospital Center metastatic lung adenocarcinoma's population.

Enrollment: 114 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Lung adenocarcinoma
• Patients diagnosed at a metastatic stage
• Patient who benefited an oncogenic driver research on their histologic samples
• Medical follow-up entirely done in Nancy Central Hospital

Exclusion criteria

• Patients with double histology
• Synchronous cancer
• Patients with surgical care