Distribution of Highly Sensitive Troponin in the Critically Unwell & Associated Mortality (DIGNITY)

U

University Hospital Southampton NHS Foundation Trust

Status

Unknown

Conditions

Myocardial Infarction
Myocardial Injury

Study type

Observational

Funder types

Other

Identifiers

NCT03630237
RHM CAR0557

Details and patient eligibility

About

The current diagnostic criteria for a heart attack require evaluation of a patient's symptoms and ECG but importantly a blood test called troponin. With advancing technology this test has become more sensitive and is now called a high sensitivity troponin. This is a very effective way of rapidly excluding a heart attack if the test is negative. However there are a number of causes of a raised high sensitivity other than a heart attack, particularly critical illness states. In the absence of features of a heart attack an abnormal result therefore suggests that the heart is inflamed or unwell causing the release of high sensitivity troponin. The DIGNITY study will examine the consequences of high sensitivity troponin elevation in patients in intensive care and assess whether it has a role as a biomarker for predicting outcome.

Enrollment

1,500 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Adult patients (aged 18 years or older) admitted to any of the three intensive care facilities on site (general, cardiac and neurosciences)
  • Biochemistry samples already taken as part of routine clinical care during the ICU stay

Exclusion criteria

  • Patients aged less than 18 years
  • No biochemistry samples taken within the ICU stay

Trial design

1,500 participants in 1 patient group

Intensive care population
Description:
All patients admitted to any of the three adult intensive care units (general, cardiac & neurosciences) at a large teaching hospital. These patients will have a high sensitivity troponin added onto biochemistry samples requested by the clinical team.

Trial contacts and locations

1

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Central trial contact

Zoe Nicholas; Jonathan Hinton

Data sourced from clinicaltrials.gov

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