Distribution of Nutrient Derived Amino Acids

Bispebjerg Hospital

Status: Completed

Conditions: Protein Breakdown; Muscle Mass; Protein Intake; Protein Synthesis; Diet Modification; Sarcopenia

Treatments: Other: Distribution pattern of dietary proteins (minced meat)

Study type: Interventional

Funder types: Other

Identifiers

NCT03870425

BBH 140

Details and patient eligibility

About

The project examines over several days how the distribution pattern of dietary protein stimulate and affect the protein turnover of important proteins in the aging perspective, such as skeletal muscle proteins.

Enrollment: 24 patients

Sex: All

Ages: 65 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Men and women
• Between 65-80 years of age

Exclusion criteria

• BMI above 30
• Smokers
• Vegetarians
• Diabetes or other metabolic diseases
• Medical treatment which affects protein turnover
• Gastro-intestinal diseases, reduced kidney or liver function, or chronic inflammation diseases
• Elevated blood-pressure or signs of atherosclerosis
• More than 5 hours of regular exercise each week

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

---

24 participants in 2 patient groups, including a placebo group

MINCED-SKEWED

Placebo Comparator group

Description:

Minced meat administered with a skewed protein distribution pattern

Treatment:

Other: Distribution pattern of dietary proteins (minced meat)

MINCED-EVEN

Experimental group

Description:

Minced meat administered with an even protein distribution pattern

Treatment:

Other: Distribution pattern of dietary proteins (minced meat)