Distribution of Topical Nasal Medication Within the Nasal Cavity and Sinuses by Radiographic Comparison

University of Nebraska

Status: Completed

Conditions: Chronic Sinusitis

Treatments: Drug: Omnipaque 240 Contrast Solution; Drug: Omnipaque 240 mg I/mL; Radiation: Sinus CT Scan

Study type: Interventional

Funder types: Other

Identifiers

NCT00626366

0498-07-FB

Details and patient eligibility

About

The purpose of this study is to determine the distribution of nasal sprays and nasal drops when used.

Full description

The purpose of this study is to determine the distribution of nasal sprays and nasal drops when used. The study hypothesizes that nasal drops will reach the frontonasal region more often than nasal sprays.

Enrollment: 18 patients

Sex: All

Ages: 19+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• adult able to perform activities of daily living

Exclusion criteria

• signs or symptoms of acute or chronic paranasal sinus disease
• history of sinus surgery
• symptomatic deviated septum
• active seasonal allergies
• allergies to contrast
• history of nasal polyposis
• pregnant or breast feeding women
• neck or back problems that would prevent a subject from kneeling on the floor and crouching over
• currently taking metformin or amiodarone
• students or stff under the direct supervision of the investigators
• cognitive impairment
• terminal illness

Trial design

Primary purpose: Other

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: Single Blind

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18 participants in 2 patient groups

Nasal spray

Experimental group

Description:

This arm of the study will contain subjects who will spray 2-4 sprays of a nasal contrast solution in their nares. Following administration of the spray, the subjects will then have a Xoran mini-CAT scan of their sinuses.

Treatment:

Radiation: Sinus CT Scan

Drug: Omnipaque 240 Contrast Solution

Nasal drop

Experimental group

Description:

This arm will contain subjects who will place two drops of a nasal contrast solution in each nose. Following administration of the nasal contrast, the subjects will then have a Xoran miniCAT scan of their sinuses.

Treatment:

Drug: Omnipaque 240 mg I/mL

Radiation: Sinus CT Scan