Disturbance of Water and Sodium Metabolism After Surgery of Sellar Lesions, and Correspond Clinical Strategy

Southern Medical University

Status: Unknown

Conditions: The Patients Suffered With Sellar Diseases; The Fluid and Electrolyte Imbalance Happened After Surgery

Treatments: Biological: Chemical and physical detection

Study type: Observational

Funder types: Other

Identifiers

NCT01406041

The department of Neurosurgery

Details and patient eligibility

About

The fluid and electrolyte imbalance (FEI) is pretty common encountered during the clinical process of patients suffered sellar lesions. Moreover, if the patients are undergone the surgery for remove the lesion, FEI happens in all cases without exception. Hypo- and hyper-natremia is the most common electrolyte disorder, which is directly correlated to the patients' outcome. However, in clinical works, different sellar diseases cause variant features of FEI. For example, after the surgery of craniopharyngioma, the hyponatremia and hypernatremia always happen alternatively even without any precursor manifestation. Under this situation, it is quite difficult for fluid supplement. In contrast, the severe FEI will cause poor outcome, even death. So it is necessary to systematically collect and review the clinical data of sellar lesions. Through the analysis of variant FEI patterns of sellar diseases, more precise strategy for clinical fluid replacement will be proposed.

Enrollment: 350 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• 1. Suffered with sellar disease
• 2. Udergone surgery
• 3. Have sufficient presurgical and postsurgical clinical data (Including MRI, CT, physical and chemical detection results)

Exclusion criteria

• 1. Without sufficitent clincal data
• 2. No surgery

Trial design

350 participants in 1 patient group

Diseases

Description:

1. Pituitary adenomas; 2. Craniopharyngioma; 3. Sellar germinoma; 4. Sellar tuberalis meningioma; 5. Hypophystis; 6. Sellar glioma; 7. Rathke's cleft cyst; 8. Hypothalamic hamartoma

Treatment:

Biological: Chemical and physical detection