Disturbed Blood Flow Induces Endothelial Dysfunction in Severe Chronic Obstructive Pulmonary Disease

University of Split

Status: Completed

Conditions: Chronic Obstructive Pulmonary Disease

Treatments: Other: oxygen; Other: retrograde flow

Study type: Interventional

Funder types: Other

Identifiers

NCT03004352

ED-COPD

Details and patient eligibility

About

The aim of the study is to determine if increased retrograde shear would further deteriorate the already impaired vascular function in severe COPD patients.

Enrollment: 27 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• COPD
• chronic hypoxemia

Exclusion criteria

• an acute exacerbation, active respiratory infection or infection of other localisation 6 weeks prior to the visit
• relevant coexisting lung disease such as interstitial lung disease, cancer, renal failure, thromboembolic disease or major cardiovascular event during the previous year
• informed consent not provided or inability to comply with the study protocol

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

---

27 participants in 6 patient groups

control subjects-retrograde flow

Experimental group

Description:

Retrograde flow was induced in control subjects.

Treatment:

Other: retrograde flow

control subjects-control

No Intervention group

hypoxemic COPD-retrograde flow

Experimental group

Description:

Retrograde flow was induced in hypoxemic COPD patients.

Treatment:

Other: retrograde flow

hypoxemic COPD-control

No Intervention group

normoxemic COPD-retrograde flow with oxygen

Experimental group

Description:

Retrograde flow was induced in COPD patients with normalized arterial oxygen saturation.

Treatment:

Other: retrograde flow

Other: oxygen

normoxemic COPD-control with oxygen

Experimental group

Description:

COPD patients with normalized arterial oxygen saturation.

Treatment:

Other: oxygen