Diurnal Variability in the Regulation of Beta-cell Function and Insulin Sensitivity in Overweight People (24Hr)

The Washington University

Status: Completed

Conditions: Overweight

Study type: Observational

Funder types: Other

Identifiers

NCT02011581

2011-09110

Details and patient eligibility

About

The purpose of this research study is to learn more about how our body produces sugar, breaks down fat for fuel, and makes insulin (the major hormone that controls the production of blood sugar and fat breakdown) during a 24-hour day and how body fat and muscle are involved in these processes.

Full description

The purpose of this study is to determine whether there are diurnal differences in postprandial beta-cell function and hepatic insulin sensitivity and the factors that influence these metabolic functions, including insulin signaling, adipose tissue and systemic inflammation, nicotinamide phosphoribosyltransferase (NAMPT)-mediated nicotinamide adenine dinucleotide(NAD) biosynthesis, and sirtuin (silent mating type information regulation 2 homolog 1 (SIRT1)) in overweight human subjects.

Enrollment: 16 patients

Sex: Female

Ages: 18 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Females
• 18-55 years old
• BMI between 25.0-29.9 kg/m2
• Must be sedentary (regular exercise <1hour/week or <2 times/week

Exclusion criteria

• Regular exercise (>1hour/week or >2 times/week)
• Diabetes
• Severe organ dysfunction
• Smokers
• Severe hypertriglyceridemia (>300 mg/dl)
• Medications that may alter the results of the study
• Pregnant
• Breastfeeding