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Diurnal Variation of Uremic Solutes in Peritoneal Dialysis

U

Universitaire Ziekenhuizen KU Leuven

Status

Completed

Conditions

Chronic Kidney Disease

Study type

Observational

Funder types

Other

Identifiers

Details and patient eligibility

About

Study on the daytime variation of uremic retention solutes and markers of bone-mineral metabolism in patients with end-stage kidney disease treated with peritoneal dialysis

Full description

Many epidemiological studies have pointed to the association between serum parameters of phosphate metabolism (phosphate, FGF23) and microbiotic protein fermentation (p-cresyl sulphate [PCS], indoxyl sulphate [IS]) on the one hand and increased risk of all-cause and cardiovascular death on the other hand.

Hypothesis: Due to failing feed-back mechanisms, diurnal variation of serum concentrations of serum phosphate and fermentation metabolites will be more pronounced in dialysis patients, especially in those with negligible residual kidney function.

Clinical studies assessing this issue are scarce to non-existing.

Enrollment

18 patients

Sex

All

Ages

18 to 55 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Age 18-55
  • Normal dietary habits

Exclusion criteria

  • Treatment with systemic antibiotics within one month Major abdominal surgery Drugs known to affect gastrointestinal physiology (acid secretion inhibitors, prokinetics, laxatives, probiotics, prebiotics,..)

Trial design

18 participants in 2 patient groups

chronic kidney disease
Description:
ESKD patients treated with peritoneal dialysis
Healthy volunteers
Description:
healthy volunteers, aged 18 years and above

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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