Diurnal Variation of Uremic Solutes in Peritoneal Dialysis

Universitaire Ziekenhuizen KU Leuven

Status: Completed

Conditions: Chronic Kidney Disease

Study type: Observational

Funder types: Other

Identifiers

NCT01093456

ML6275

Details and patient eligibility

About

Study on the daytime variation of uremic retention solutes and markers of bone-mineral metabolism in patients with end-stage kidney disease treated with peritoneal dialysis

Full description

Many epidemiological studies have pointed to the association between serum parameters of phosphate metabolism (phosphate, FGF23) and microbiotic protein fermentation (p-cresyl sulphate [PCS], indoxyl sulphate [IS]) on the one hand and increased risk of all-cause and cardiovascular death on the other hand.

Hypothesis: Due to failing feed-back mechanisms, diurnal variation of serum concentrations of serum phosphate and fermentation metabolites will be more pronounced in dialysis patients, especially in those with negligible residual kidney function.

Clinical studies assessing this issue are scarce to non-existing.

Enrollment: 18 patients

Sex: All

Ages: 18 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age 18-55
• Normal dietary habits

Exclusion criteria

• Treatment with systemic antibiotics within one month Major abdominal surgery Drugs known to affect gastrointestinal physiology (acid secretion inhibitors, prokinetics, laxatives, probiotics, prebiotics,..)

Trial design

18 participants in 2 patient groups

chronic kidney disease

Description:

ESKD patients treated with peritoneal dialysis

Healthy volunteers

Description:

healthy volunteers, aged 18 years and above