Genome Analysis Across Populations in Inflammatory Bowel Disease

Mount Sinai Hospital, Canada

Status: Enrolling

Conditions: Healthy; Ulcerative Colitis; Inflammatory Bowel Diseases; Crohn Disease

Treatments: Genetic: Blood or saliva sample collection

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT06042387

02-0234-E

U01DK062423 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

Objective:

To use clinical, genetic and genome analysis to better understand and define the genetic and environmental factors that contribute to IBD within affected populations.

Full description

Background:

Inflammatory bowel disease (IBD) is a chronic, and often disabling, disorder of the intestines characterized by dysregulation of mucosal immune response. Recent data suggests that the incidence and prevalence rates among all populations may be increasing due to constantly changing environmental exposures. The goal of the study is to identify susceptible genes that contribute to the pathogenesis of IBD in affected individuals.

Enrollment: 150 estimated patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Subjects: diagnosed with Inflammatory Bowel Disease (Crohn's disease, ulcerative colitis, IBD-undetermined)
• Available medical records to confirm IBD diagnosis (Crohn's disease, Ulcerative colitis, IBD undetermined (IBD-U))
• Healthy controls: no personal history of IBD, no family history of IBD, no history of unexplained chronic diarrhea/blood in stool/anemia/abdominal pain/weight loss
• Any age

Exclusion criteria

• Subjects with other gastrointestinal conditions not meeting the above IBD or Healthy Control criteria

Trial design

150 participants in 2 patient groups

IBD Subjects

Description:

Available medical records to confirm IBD diagnosis (Crohn's disease, Ulcerative colitis, IBD undetermined (IBD-U)) Any age Willing to provide blood or saliva sample

Treatment:

Genetic: Blood or saliva sample collection

Controls

Description:

No personal history of IBD, no family history of IBD, no history of unexplained chronic diarrhea/blood in stool/anemia/abdominal pain/weight loss Any age Willing to provide blood or saliva sample

Treatment:

Genetic: Blood or saliva sample collection