Diversity Analysis of Vaginal Microbiota on Women With High-risk Human Papillomavirus Infection

Chinese Academy of Medical Sciences & Peking Union Medical College

Status: Unknown

Conditions: Papillomavirus Infections

Treatments: Biological: Human Papillomavirus

Study type: Observational

Funder types: Other

Identifiers

NCT03548740

WS-1

Details and patient eligibility

About

Since other genital infections enhance HIV susceptibility by inducing inflammation, the investigators study the relationship between the vaginal microbiota composition and the risk of HPV infection, cervical cytological abnormalities.

Full description

Persistent infection with oncogenic Human Papillomavirus (HPV) is necessary but not sufficient for the development of cervical cancer. Additional factors correlated with HPV persistence include immunodeficiency caused by HIV, smoking, use of oral contraceptives and, more recently reported, vaginal dysbiosis. In a state of dysbiosis, there is a marked reduction of Lactobacillus and a high diversity of bacteria, with increased abundance of anaerobic bacterial species. Based on this, the investigators are going to analyze the changes of microbiota in women with high-risk HPV and the cervical lesions. And the investigators hope to figure out the difference and change in microbiota to realize the tanning of cervical lesions.

Enrollment: 151 estimated patients

Sex: Female

Ages: 25 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Clinical diagnosis of HR-HPV results.

Exclusion criteria

Clinical diagnosis of vaginitis, immune disease, malignancy History of cervical lesions Pregnancy Clinical diagnosis of other serious systemic primary diseases, such as severe liver and kidney dysfunction Severe mental illness

Trial design

151 participants in 2 patient groups

Group A

Treatment:

Biological: Human Papillomavirus

Group B