DNA Methylation and 1-C Metabolism Nutrient Intake

Cancer Council Victoria

Status: Completed

Conditions: DNA Methylation

Study type: Observational

Funder types: Other

Identifiers

NCT03227003

CEID_methylation_1

Details and patient eligibility

About

The present study used a sub-sample of the Melbourne Collaborative Cohort Study (MCCS) (Milne RL et al, Int J Epidemiol, 2017), who had valid data on dietary intakes (121-item food frequency questionnaire) and valid measures of DNA methylation using the HumanMethylation Infinium 450K Beadchip assay, or using LINE-1, Alu and Sat2 assays.

The investigators studied the association between nutrients involved in one-carbon metabolism and DNA methylation in peripheral blood.

Enrollment: 5,983 patients

Sex: All

Ages: 27 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Selected into one of six case-control studies nested in the Melbourne Collaborative Cohort Study
• Completed a 121-item Food Frequency Questionnaire
• Had a blood DNA sample with a measure of methylation

Exclusion criteria

• Missing data in any of the outcome, exposure, or confounders (N=797 excluded)