DNA Methylation and Hydroxymethylation Levels in Patients With Coronary Heart Disease

Chongqing Medical University

Status: Completed

Conditions: Coronary Heart Disease

Study type: Observational

Funder types: Other

Identifiers

NCT03462277

2016-39

Details and patient eligibility

About

The purpose of this trial is to investigate the relationship between DNA methylation and hydroxymethylation and the expression of DNMTs, TET family gene and the degree of coronary heart disease.

Full description

1. To determine the levels of DNA methylation and hydroxymethylation with coronary heart disease.
2. To investigate the relationship between DNA methylation and hydroxymethylation and the degree of coronary atherosclerosis.

Enrollment: 200 patients

Sex: All

Ages: 65+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Male and Female. Patients older than 65 years old who are willing to participate in the study. CHD patients was defined as at least one lesion in a coronary artery or branches in coronary angiograms. Control group was defined as people with negative findings in coronary angiograms.

Exclusion criteria

Patients with concurrent infection or any documented inflammatory illness, such as arthritis or connective tissue diseases, or any other malignancy. Patients with a history of cardiomyopathy. Pregnant women. Severe hepatic dysfunction or End-stage renal failure. Uncontrolled hypertension.

Trial design

200 participants in 2 patient groups

Control group

Description:

Control group was defined as people with negative findings in coronary angiograms.

Coronary Heart Disease group

Description:

CHD patients was defined as at least one lesion in a coronary artery or branches in coronary angiograms.