DNA Methylation and Urothelial Carcinoma

China Medical University

Status: Unknown

Conditions: Urothelial Carcinoma

Study type: Observational

Funder types: Other

Identifiers

NCT01378052

DMR100-IRB-092

Details and patient eligibility

About

Many studies previously showed the significant association between urinary arsenic profiles and urothelial carcinoma (UC) risk and observed the increased UC risk in people with lower plasma folate and higher homocysteine than those with higher plasma folate and lower homocysteine. The investigators would expect to explore the interactions among global DNA methylation, one-carbon metabolic pathway factors, urinary arsenic profiles and UC.

Enrollment: 200 estimated patients

Sex: All

Ages: 21+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Clinical diagnosis of urothelial carcinoma
• The voluntary of participating the study

Exclusion criteria

• Age smaller than 20 years
• Pregnant women
• Not willing to participate the study because of their personal reasons

Trial design

200 participants in 2 patient groups

urothelial carcinoma pateints

healthy controls

Description:

Age and gender matched control subjects with no evidence of UC or any other malignancy were accrued from the hospital, recruiting people receiving adult health examinations at China Medical University Hospital.