DNA Methylation Combined With Artificial Intelligence Imaging to Identify Lung Nodules (MAGIC)

Nanjing Medical University

Status

Enrolling

Conditions

Lung Cancer Diagnosis

Treatments

Diagnostic Test: DNA methylation joint AI imaging

Study type

Observational

Funder types

Other

Identifiers

NCT06220305

2023SR257

Details and patient eligibility

About

Lung cancer is the leading cause of cancer deaths,and the key to reducing mortality in lung cancer patients is early diagnosis and treatment.Currently,peripheral blood DNA methylation is a novel in vitro molecular marker for tumors.Meanwhile artificial intelligence diagnostic system can further improve the diagnostic ability.The purpose of this study is to apply the overall DNA methylation level (i.e.,methylation profile) and the altered methylation degree of specific genes as tumor diagnostic indexes,and combined with the artificial intelligence imaging technology for the early and accurate diagnosis of lung cancer,to achieve the early detection,diagnosis,and treatment of lung cancer,and to effectively reduce the mortality rate of lung cancer.

Enrollment

100 estimated patients

Sex

All

Ages

20 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

(1) Patients with pulmonary nodules diagnosed by imaging;
(2) No contraindications to blood collection;
(3) Voluntary completed DNA methylation testing;
(4) Signed informed consent and performed all the study mandated procedures.

Exclusion criteria

(1) Pregnant or lactating(6 months) women;
(2) History of malignancy or known malignancy or precancerous lesions or known tuberculosis within 3 years;
(3) Autoimmune system disorders;
(4) Undergoing any diagnostic puncture therapy, such as percutaneous lung biopsy, transbronchial, pre-enrollment biopsy, or surgical procedures (within 6 months); (5) Recipients of organ transplants or prior non-autologous (allogeneic) bone marrow transplants or stem cell transplants; (6) Received antibiotic therapy within 14 days or applied a drug that elevates white blood cells within 45 days prior to the blood draw.