DNA Methylation Trajectories in Aging (EPI-GERAS)

University of Campania "Luigi Vanvitelli"

Status: Not yet enrolling

Conditions: Aging; Heart Failure

Treatments: Other: RRBS

Study type: Observational

Funder types: Other

Identifiers

NCT06582992

Aging Well in an Aging Society

Details and patient eligibility

About

The goal of this observational study is to profile changes in DNA methylation of circulating CD4+ T and CD8+ T cells from healthy young to aged with diagnosis of HFpEF, a particular phenotype of HF which is highly prevalent in aging.

The main question it aims to answer is:

-Do DNA methylation biomarkers help us to understand the role of inflammation in HFpEF during aging?

Our goal is to provide a simple large-scale panel of epigenetic-sensitive biomarkers useful in aged patients with HF in the early natural history of the disease (HFpEF).

Enrollment: 150 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Healthy subjects aged between 18 and 40 years
• Aged subjects (≥65) without signs and symptoms of heart failure
• Aged subjects (≥65) with diagnosis of heart failure with preserved ejection fraction (EF major than 50%)

Exclusion criteria

• Heart failure with reduced ejection fraction (EF minor than 40%)
• Heart failure with mildly reduced EF (HFmrEF) (EF 41-49%)
• History or diagnosis of cancer and inflammatory diseases

Trial design

150 participants in 3 patient groups

Young healthy subjects

Description:

This cohort is characterized by 50 healthy subjects aged \< 40 years (blood donor volonteers)

Treatment:

Other: RRBS

Aged healthy subjects

Description:

This cohort is characterized by 50 healthy subjects aged \> 60-65 years (blood donor volonteers) without signs and symptoms of heart failure

Treatment:

Other: RRBS

Patients with heart failure

Description:

This cohort is characterized by 50 subjects aged \> 60-65 years with signs and symptoms of heart failure with preserved ejection fraction

Treatment:

Other: RRBS