Do CCR5 Antagonists Improve the Overall Survival of Patients With AIDS-related Progressive Multifocal Leucoencephalopathy?

Fondation Ophtalmologique Adolphe de Rothschild

Status: Completed

Conditions: AIDS; Progressive Multifocal Leucoencephalopathy (PML)

Treatments: Other: Measure of overall survival

Study type: Observational

Funder types: NETWORK

Identifiers

NCT03969550

29305436

Details and patient eligibility

About

Progressive multifocal leucoencephalopathy (PML) is a demyelinating disease caused by John Cunningham virus (JCV) reactivation. Numerous molecules have been overstated because there were inaccurately tested in non-rigorous clinical trial.

The objective is to draw lessons from repeatedly false hopes of unconfirmed PML treatments that might contribute to prescribing ineffective drugs on claimed efficacy in case reports or small series and by failing to respect the need for clinical trial evaluation before authorizing their widespread use.

Enrollment: 34 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• Patients with AR-PML
• Diagnosed between January 2008 and December 2015
• Followed in one of the four University Hospitals' Infectious Diseases Departments

Exclusion Criteria: