Do Increasing Preoperative Timing of Single Dexmedetomidine Dose Have an Effect on Stress Response of Laryngoscopy and Intubation?

Tanta University

Status: Enrolling

Conditions: Time; Dexmedetomidine; Stress Response; Intubation; Laryngoscopy

Treatments: Drug: Dexmedetomidine; Drug: Saline

Study type: Interventional

Funder types: Other

Identifiers

NCT07165483

36264PR1334/8/25

Details and patient eligibility

About

This study aims to evaluate the effect of increasing preoperative timing of single dexmedetomidine on the stress response of laryngoscopy and intubation.

Full description

Maintaining hemodynamic stability during surgery is one of the most important tasks because good anesthesia increases the success rate of surgery and improves postoperative prognosis.

Dexmedetomidine, a potent α2-adrenoreceptor agonist, produces not only a sedative-hypnotic effect, but in situations involving cardiac risk, it also produces analgesic effects and an autonomic blocking effect, by acting on a single type of receptor.

Enrollment: 45 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age from 18 to 65 years.
• Both sexes.
• American Society of Anesthesiology (ASA) physical status I-II.

Exclusion criteria

• Severe cardiovascular problems.
• Respiratory disorders.
• Diabetes.
• Hypertension.
• Obesity.
• Allergic reaction to study drugs.
• Patients on antihypertensive medication (α-methyldopa, clonidine, or other α2-adrenergic agonists)
• Medications that affect heart rate (HR) or blood pressure (BP).
• Pregnant.
• Currently breast-feeding women.
• History of sleep apnea.
• Those for emergency procedures.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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45 participants in 3 patient groups, including a placebo group

Group D20

Experimental group

Description:

Patients will receive 0.5µg/kg dexmedetomidine (over 10 min) 20 min before induction of anesthesia then saline (over 10 min) 10 min before induction of anesthesia.

Treatment:

Drug: Dexmedetomidine

Drug: Dexmedetomidine

Group D10

Experimental group

Description:

Patients will receive saline (over 10 min) 20 min before induction of anesthesia then 0.5µg/kg dexmedetomidine (over 10 min) 10 min before induction of anesthesia.

Treatment:

Drug: Dexmedetomidine

Drug: Dexmedetomidine

Group C

Placebo Comparator group

Description:

Patients will receive saline before induction of anesthesia as a control group.

Treatment:

Drug: Saline