Do Topical Antibiotics Improve Skin Graft Results?

LAMB Project

Status: Completed

Conditions: Antibiotic Prophylaxis Surgery; Skin Transplantation; Wounds and Injuries

Treatments: Drug: Neomycin

Study type: Observational

Funder types: Other

Identifiers

NCT07286851

REC2025/03

Details and patient eligibility

About

The goal of this study is to see if putting antibiotic ointment on a skin graft when the surgery is being done helps prevent the skin graft from getting infected after the operation. The study is looking at all skin grafts done in a rural Bangladesh hospital.

The main questions it aims to answer are:

Does the antibiotic lower the number of infections that happen? Does the antibiotic make the overall outcome of the skin graft better? Do patients who get the antibiotic need fewer extra surgeries?

Researchers will compare the outcomes from patients who had skin grafts before the hospital started applying antibiotic ointment to the outcomes of patients after the hospital began applying antibiotic ointment.

Participants who have already had their skin graft treatment completed will have their medical records reviewed by researchers. The outcomes of their treatment will be written down.

Enrollment: 142 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• patient undergoing a split-thickness skin graft at the hospital where research is conducted

Exclusion criteria

• Missing or incomplete medical record

Trial design

142 participants in 2 patient groups

Control

Description:

Patients who had skin graft procedure before the topical antibiotic protocol was initiated

Neomycin

Description:

Patients who had skin graft procedure after the topical antibiotic protocol was initiated. Patients had topical neomycin applied at the time of their surgeries.

Treatment:

Drug: Neomycin