Does Abatacept Induce Regulatory B Cells in Patients With Rheumatoid Arthritis (ABATACEPT_B)

Regional University Hospital Center (CHRU)

Status: Completed

Conditions: Rheumatoid Arthritis

Study type: Observational

Funder types: Other

Identifiers

NCT02885818

ABATACEPT AND B CELL

Details and patient eligibility

About

Abatacept disrupts T-cell coactivation signals in rheumatoid arthritis (RA). Its potential effects on B cells are not well described. This study will assess the effects of abatacept therapy on the phenotype and function of peripheral blood B cells in patients with RA.

Enrollment: 20 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• RA as defined by ACR/EULAR criteria
• Clinical indication to start abatacept therapy

Exclusion criteria

• Treatment by rituximab in the previous year