Does Adding Magnesium Sulphate to Low Dose Rocuronium Affects Depth of Blockade

National Cancer Institute, Egypt

Status: Completed

Conditions: Anesthesia

Treatments: Drug: standard rocuronium dose; Drug: Magnesium sulfate

Study type: Interventional

Funder types: Other

Identifiers

NCT04510337

201617031.2P

Details and patient eligibility

About

This study aim is to compare the effect of magnesium sulphate combined with low dose rocuronium versus standard dose rocuronium

Full description

Comparing the effect of magnesium sulphate combined to low dose rocuronium versus standard dose rocuronium in cancer patients undergoing direct laryngoscopy for laryngeal tumors regarding intubating conditions, intraoperative relaxation, depth of anesthesia and recovery time.

Enrollment: 60 patients

Sex: All

Ages: 30 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Patients with Laryngeal tumors

ASA I-II

Age 30-70 years

Exclusion criteria

Renal and or hepatic insufficiency

Neuromuscular disease

Large glottic and/or supra-glottic lesions with or without breathing difficulties

Known allergy to any of the used drug

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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60 participants in 2 patient groups

Standard rocuronium

Active Comparator group

Description:

patients received rocuronium 0.6mg/kg

Treatment:

Drug: standard rocuronium dose

Magnesium

Experimental group

Description:

patients received 100 ml saline with 50mg/kg magnesium sulphate infusion over 10 minutes

Treatment:

Drug: Magnesium sulfate