Does APOE-e4 Predict Delirium and Cognitive Dysfunction After Surgery?

Ottawa Hospital Research Institute

Status: Completed

Conditions: Delirium; Postoperative Cognitive Dysfunction

Study type: Observational

Funder types: Other

Identifiers

NCT00911677

OHREB 2004800-01H

Details and patient eligibility

About

Patients with the APOE-ε4 genotype are at increased risk of both vascular dementia and peripheral vascular disease. Patients undergoing major vascular surgery are at particularly high risk of delirium and other, more subtle, changes in cognitive function following surgery. The hypothesis of this trial is that the APOE-ε4 genotype is associated with both delirium and postoperative cognitive dysfunction (POCD).

Enrollment: 100 patients

Sex: All

Ages: 60+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age 60 or greater
• Open repair of the abdominal aorta

Exclusion criteria

• refusal;
• planned endovascular repair;
• emergency surgery;
• previous diagnosis of dementia, Parkinson's disease, or psychiatric illness;
• active alcohol or substance abuse; and
• physical inability to complete neuropsychometric testing.

Trial design

100 participants in 1 patient group

Open Aortic Repair

Description:

Patients 60 years of age and older undergoing open repair of the abdominal aorta