Does Caffeine Affect the Sensitivity of Adenosine Perfusion Scans?

University of Wisconsin (UW)

Status: Completed

Conditions: Coronary Artery Disease

Treatments: Drug: Caffeine; Procedure: Cardiac SPECT imaging Rest and Stress

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT00205166

1999-109

Details and patient eligibility

About

We are studying the affect of caffeine on the sensitivity of detecting coronary artery disease (blockages in the blood flow to the heart) with adenosine tracer scans. Adenosine is a drug used routinely in patients to relax heart blood vessels in order to assess for the presence of coronary artery disease. Often, if patients have had caffeine, the adenosine scan is not used because of the belief that caffeine may reduce the ability to detect coronary artery disease. We would like to test whether caffeine affects our ability to detect coronary artery disease with adenosine tracer scanning. We will perform an imaging study of the heart with adenosine after you have received caffeine.

Enrollment: 50 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients who have already completed rest/stress 99mTc sestamibi or 99mTc tetrofosmin imaging will be given a form describing this protocol and asked to volunteer for the additional scan

Exclusion criteria

• history of asthma, bronchospastic COPD, or renal failure

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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50 participants in 2 patient groups

1

Active Comparator group

Description:

Caffeine 400 mg PO 1 hour before adenosine infusion

Treatment:

Drug: Caffeine

Procedure: Cardiac SPECT imaging Rest and Stress

Drug: Caffeine

2

Active Comparator group

Description:

Caffeine 200 mg po one hour before adenosine infusion

Treatment:

Drug: Caffeine

Procedure: Cardiac SPECT imaging Rest and Stress

Drug: Caffeine