Does Coffee Intake Reduce Postoperative Ileus After Elective Colorectal Surgery (COFFEE)

Kantonsspital Baden

Status: Completed

Conditions: Postoperative Ileus

Study type: Observational

Funder types: Other

Identifiers

NCT02469441

2014-062

Details and patient eligibility

About

The aim of the study is to investigate if postoperative coffee intake decreases the time until first bowel movement in elective colorectal surgery with primary anastomosis.

Full description

Postoperative ileus after colorectal surgery is a frequent problem which significantly prolongs hospital stay and increases perioperative costs. Postoperative therapeutic interventions vary significantly between different hospitals due to missing evidence-based guidelines. Coffee is a safe, cheap and simple agent without significant side effects which can positively influence the bowel function.

The aim of the investigators is to evaluate in an own study if coffee consumption has an influence on the duration of postoperative ileus.

The present trial is designed to evaluate if postoperative coffee intake decreases the time until first bowel movement in colorectal surgery with primary anastomosis. This study would be the second study which evaluates the described questions under randomized conditions.

Enrollment: 136 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Patients scheduled for elective laparoscopic or open colorectal surgery due to benign or malignant colorectal disease, which need a large bowel resection with primary anastomosis

• Age equal or greater than 18 years
• Patients that are able to give informed consent
• Elective Surgery
• Anastomosis above 6 cm from anal verge

Exclusion criteria

• Participation in other studies
• Additional small bowel anastomosis
• Need for extended adhesiolysis
• Need for a stoma (e.g. protective ileostomy)
• Emergency operation with diffuse peritonitis or preexisting ileus
• Preoperative radiation
• Known hypersensitivity or allergy to coffee
• Expected lack of compliance
• Impaired mental state or language problems

Trial design

136 participants in 2 patient groups

Arm A

Description:

Arm A (treatment arm: coffee): patients after colorectal surgery receive coffee in addition to the regular infusion therapy and/or alimentation

Arm B

Description:

Arm B (control arm: water / tea): patients after colorectal surgery receive water or tea (excluding black tea) and no coffee until the first bowel movement in addition to the regular infusion therapy and/or alimentation