Does Consuming Modified Plant Seed Oil Containing Fish Oil Fatty Acids Act in the Same Way as Consuming Fish Oil?

University of Southampton

Status

Completed

Conditions

Healthy

Treatments

Dietary Supplement: single dose Camelina seed oil

Dietary Supplement: repeated dose camelina seed oil

Dietary Supplement: Repeated dose fish oil

Dietary Supplement: Single dose fish oil

Study type

Interventional

Funder types

Other

Identifiers

NCT03477045

17497

Details and patient eligibility

About

Fish oil and oily fish contain omega 3 long chain polyunsaturated fatty acids known to be beneficial to health. Many people consume little, despite UK government recommendations to eat at least one portion of oily fish per week. Furthermore, despite modest consumption, fish stocks are declining due to over fishing. Therefore, there is a need for an alternative, sustainable and cost efficiently produced dietary source. A seed oil source of these fish oil-type fatty acids has been achieved by adding genes from other plant sources to the oil seed plant Camelina sativa. Camelina sativa, related to mustard and cabbage, has provided seed oil for human consumption for thousands of years. It was the most important oil seed plant in Europe until the 1900's. This research is being done to see if consuming fish oil-type fatty acids in Camelina seed oil allows the body to take up and use the fish oil fatty acids in the same way as it does from fish oil.

Full description

This research is being done to see if consuming fish oil-type omega 3 long chain polyunsaturated fatty acids in Camelina seed oil allows the body to take up the fish oil fatty acids in the same way as it does from fish oil.

In the first study (A) the Camelina oil will be used in a meal. The volunteers (healthy men and women) will be asked to consume the meal and provide blood samples in the following 6 hours to look at immediate uptake of the fish oil fatty acids. This will be repeated (for comparison) with fish oil.

The second study (B) will look at consumption over a longer period. Volunteers will be asked to consume the Camelina oil daily for 8 weeks and provide blood samples at the visits at the start and end of that period. This will be repeated (for comparison) with fish oil.

Enrollment

31 patients

Sex

All

Ages

18 to 65 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Male or female
18 to 30 years or 50 to 65 years
Body mass index 18.5-30.0 kg/m2
Health screening results that are within normal clinical ranges
Not consuming fish oil or other oil supplements
Not eating more than one oily fish meal per week
Willing to adhere to the study protocol
Being able to provide written informed consent

Exclusion criteria

Aged < 18 years; 31-49 years or > 65 years
Body mass index < 18.5 or > 30 kg/m2
Current smoker
Fasting blood cholesterol or glucose concentrations outside the normal concentration range
Diagnosed chronic illness (for example diagnosed cardiovascular disease, diabetes, cancer)
Use of prescribed medicine to control inflammation
Use of prescribed medication to control blood lipids (e.g. statins, fibrates (fenofibrate), Omacor)
Use of prescribed medication to control blood pressure (ACE inhibitors, angiotensin 2 receptor blockers, calcium channel blockers, α-inhibitors, thiazide diuretics)
Use of fish oil or other oil supplements
Chronic gastrointestinal problems (e.g. IBD, coeliac disease, cancer)
Pregnant or planning to become pregnant within the study period
Participation in another clinical trial