Does COVİD-19 m-RNA Vaccine Affect Fertility and Over Reserve ?

Gaziosmanpasa Research and Education Hospital

Status: Completed

Conditions: Fertility Disorders; Vaccine Adverse Reaction; Ovarian Function Insufficiency; COVID-19 Virus Infection

Treatments: Biological: sars cov 2 biontec vaccine

Study type: Observational

Funder types: Other

Identifiers

NCT05489367

GaziosmanpasaTREHm

Details and patient eligibility

About

Women's ovarian reserve and fertility were compared before and after 2 doses of vaccination

Full description

our study ıs desıgned as an observatıonal clınıcal study. the purpose ıs to compare the over reserve tests of the patıents before and after vaccıne, to determıne ıf the over reserve and fertılıty of women are affected by the vaccıne.women who applied to the vaccination outpatient clinic for the first dose of vaccine were included in the study.those who have never been vaccinated and have not had covid 19 infection were included in the study.antı ullerıan hormone level ıs the laboratory parameters that best showıng the ovary reserve today. ovarian reserve tests including amh were checked and their fertility was questioned and their information was recorded.

the same tests were repeated after the volunteers received 2 doses of vaccine. ın the power analysis, it was calculated that 104 volunteers should be included in the study.the study will be terminated when 104 volunteers are reached.

Enrollment: 64 patients

Sex: Female

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• between 18-45 years old
• have ever had a covid vaccine
• not be infected with covid 19

Exclusion criteria

• pregnancy
• diagnosis of any kind of cancer
• oral contraceptive usage
• endometrioma
• PCOS
• menopause
• menstrual irregularity
• premature ovarian insufficiency

Trial design

64 participants in 1 patient group

Pre-vaccine ovarian reserve and fertility status

Description:

Before vaccination, ovarian reserve tests and fertility status of 64 women will be examined and results will be recorded.After 2 doses of vaccination, ovarian reserve and fertility status of same 64 women will be examined and results will be recorded

Treatment:

Biological: sars cov 2 biontec vaccine