Does DNA Sperm Fragmentation Affects Embryo Morphokinetic? (MACs-ESD)

IVI Madrid

Status: Terminated

Conditions: Cleavage Times; Blastocyst Time; Pronuclear Appearance; Embryo Compaction; Pronuclear Fading

Treatments: Other: MACS

Study type: Interventional

Funder types: Other

Identifiers

NCT02214537

MADDA12201301

Details and patient eligibility

About

The embryokinetics may be a new prognostic factor for choosing the human embryos with the highest implantation potential. In order to identify the factors that may affect the rate of embryo cleavage, there are many studies about morphokinetics and culture medium, oxygen tension, oocyte quality or type of medication used for ovarian stimulation. However there are no published data with respect to the influence of sperm DNA fragmentation in the embryo kinetic.

Enrollment: 60 patients

Sex: All

Ages: 36 to 38 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients 36 to 38 years
• Fresh sample semen
• Minimum 6 oocytes
• Semen sample with at least 5 million/ml and at least 30% of progressive motile sperm.

Exclusion criteria

• Patients younger than 36 or older than 38 years old
• Frozen semen sample
• Less tan 6 oocytes.
• Semen samples with less than 5 million / ml or less than 30% of motile sperm.

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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60 participants in 1 patient group

MACS

Experimental group

Description:

Patients with MACS Selection

Treatment:

Other: MACS