Does Endometrial Injury Improve Intrauterine Insemination Outcome?

Ain Shams Maternity Hospital

Status and phase: Completed; Phase 3

Conditions: Infertility

Treatments: Procedure: intrauterine insemination; Procedure: endometrial injury.; Drug: ovarian stimulation

Study type: Interventional

Funder types: Other

Identifiers

NCT02542280

abahaa050301

Details and patient eligibility

About

The investigator suggests that local endometrial injury using pipelle catheter performed in the follicular phase (cycle day 5, 6 or 7) of the stimulation cycle may improve the pregnancy rates among patients undergoing intrauterine insemination.

Full description

In a selected group of patients with repeated implantation failure, endometrial injury in the preceding cycle may improve ICSI outcome.

Little is known about the efficacy of this procedure in improving intrauterine insemination outcome.

Also little is known about the effect of this procedure if done in the stimulation cycle weather in ICSI or intrauterine insemination cycles.

Enrollment: 360 patients

Sex: Female

Ages: 18 to 38 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 18 - 38 years.
• patent fallopian tunes.
• mild male factor.
• anovulation.
• unexplained infertility.

Exclusion criteria

• indications for ICSI.
• evidence of pelvic inflammatory disease.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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360 participants in 2 patient groups

endometrial injury

Experimental group

Description:

Endometrial injury during ovarian stimulation combined with intrauterine insemination.

Treatment:

Drug: ovarian stimulation

Procedure: endometrial injury.

Procedure: intrauterine insemination

no endometrial injury

Active Comparator group

Description:

Ovarian stimulation combined with intrauterine insemination.

Treatment:

Drug: ovarian stimulation

Procedure: intrauterine insemination