Does Increase in Appetite After Iron Treatment Induced by Ghrelin Hormone

HaEmek Medical Center, Israel

Status: Completed

Conditions: Anemia

Study type: Observational

Funder types: Other

Identifiers

NCT02734641

155-15EMC

Details and patient eligibility

About

The purpose of this study is to examine whether iron therapy in patients with intravenous iron deficiency anemia causes an increase in appetite. And whether this increase is mediated by the hormone ghrelin.

Full description

Prior to Iron treatment Investigator will sample subject blood for: counting blood, iron sector indices, renal function, electrolytes, and measure the level of ghrelin fasting plasma. In addition, the patient will fill a structured questionnaire that examines appetite levels. participants will be asked to answer a structured questionnaire which will include information on demographics, clinical data (fever, allergies, weight, height) and comorbidities. Additional data on laboratory tests, comorbidities, medication and regular blood and urine cultures results will be taken from the medical file. Iron treatment will be given according to local standard procedure . At the end of the treatment ghrelin levels and questionaire will be retaken .

iron deficiency anemia is defined: hemoglobin <12 gr / dl in women and Hb <13 gr / dl in men with ferritin <15 ng / ml.

Enrollment: 111 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Iron deficiency anemia that wasn't responded to oral treatment or wasn't tolerable due to side effects
• sign and dated informed consent form.

Exclusion criteria

• chronic inflammatory disease.
• chronic renal failure
• active cancer.
• active Infectious disease.
• non iron deficiency anemia.
• pregnancy.

Trial design

111 participants in 2 patient groups

intravenous (IV) iron therapy

Description:

Patients register to intravenous (IV) iron therapy due to iron deficiency anemia that wasn't responded to oral treatment or wasn't tolerable due to side effects. 20 mL of blood will be draw for complete blood count, renal function, electrolytes and ghrelin. In addition, the patient will fill a structured questionnaire that examines the appetite of the patient before and after treatment. At the end of Iron administration Ghrelin will be retested.

healthy volunteer

Description:

healthy volunteer, will be asked 20 mL of blood will be draw for complete blood count, renal function, electrolytes and ghrelin. In addition, the patient will fill a structured questionnaire that examines his appetite. Ghrelin will be retested after 6 weeks.