Does Increasing the Compression Pause from 3 to 5 Seconds in Mechanical Compression Devices Increase Ventilation Success Rate and Return of Spontaneous Circulation? (LUCASVP)

Amsterdam UMC, location VUmc

Status: Not yet enrolling

Conditions: Cardiac Arrest (CA)

Treatments: Other: 3-second ventilation pause duration during mechanical CPR; Other: 5-second ventilation pause duration during mechanical CPR

Study type: Interventional

Funder types: Other

Identifiers

NCT06824961

LUCASVP

Details and patient eligibility

About

To give chest compressions during cardiopulmonary resuscitation (CPR), mechanical chest compression devices can be used. During synchronous 30:2 CPR, the standard setting on these devices leave an automated 3-second chest compression pause after 30 compressions to facilitate caregivers in providing two ventilations. With this standard setting, research has shown that in less than half of ventilation pauses during CPR, those two ventilations are given. Increasing the ventilation pause duration to 5 seconds instead of 3 seconds is also an option following current guideline recommendations, and aligns with measured ventilation pause duration in manual CPR. Increasing pause duration to 5 seconds could result in an increased ventilation success rate. This multicenter randomized controlled trial will randomize LUCAS® mechanical compression devices to a standard setting of 3- or 5-second compression pauses. The main outcome will be the percentage of ventilation pauses in which two ventilations are successfully given. Secondary outcomes include the restoration of spontaneous circulation (ROSC), and the difference in (neurologically intact) survival. No study has been performed to evaluate this effect yet.

Enrollment: 692 estimated patients

Sex: All

Ages: 16+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adults (≥16 years of age)
• OHCA patients with an attempt at cardiopulmonary resuscitation (CPR) by ambulance personnel
• LUCAS® 3.1 has been used during the resuscitation attempt

Exclusion criteria

• Missing ambulance run report, missing or unclear impedance signal (measurement of resistance across the thorax), making it impossible to assess the number of ventilation pauses
• Absence of a minimum of 3 assessable pauses intended for ventilation after connecting the LUCAS®

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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692 participants in 2 patient groups

Intervention - 5-second ventilation pause

Experimental group

Description:

Patients in this group will have ventilation pauses lasting 5 seconds in between cardiac compressions given by mechanical CPR

Treatment:

Other: 5-second ventilation pause duration during mechanical CPR

Control - 3-second ventilation pauses

Active Comparator group

Description:

Patients in this group will have ventilation pauses lasting the standard 3 seconds in between cardiac compressions given by mechanical CPR

Treatment:

Other: 3-second ventilation pause duration during mechanical CPR