Does Indoxyl Sulfate Have a Role in Uremic Pruritus?

Benha University

Status: Completed

Conditions: Pruritus

Treatments: Dietary Supplement: Uremic pateints with itching

Study type: Interventional

Funder types: Other

Identifiers

NCT05634083

RC 22-10-2022

Details and patient eligibility

About

Itching is a widespread and disturbing complain from patients with chronic kidney disease (CKD); epidemiologic data have suggested that approximately 40% of patients with end-stage renal disease experience moderate to severe itching. The pathogenesis of renal pruritus is multifactorial. Triggering factors may include uremia-related abnormalities, accumulation of uremic toxins, systemic inflammation and cutaneous xerosis. Indoxyl sulfate (IS) is a protein-bound uremic toxin resulting from the metabolism of dietary tryptophan accumulating in patients with end-stage renal disease.

Full description

Patients with end-stage renal disease undergoing hemodialysis complaining of itching not related to other cause than renal failure will take activated charcoal with foods and serum level of indoxyl sulphate will be studied

Enrollment: 45 patients

Sex: All

Ages: 18 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Patients with end-stage renal failure with itching undergoing regular hemodialysis

Exclusion criteria

Patients with other causes of itching as psoriasis, atopic dermatitis, scabies, and lichen planus

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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45 participants in 1 patient group

Uremic Pateints group

Experimental group

Description:

Patients with end-stage renal failure with itching

Treatment:

Dietary Supplement: Uremic pateints with itching