Does Intralipid Infusion Can Reverse the Spinal Anesthesia Effect in Day Case Surgery?

Benha University

Status: Completed

Conditions: Spinal Anesthesia; Day Case Surgery; Intralipid Infusion

Treatments: Other: Lipid emulsion

Study type: Interventional

Funder types: Other

Identifiers

NCT07025343

RC 6-1-2025

Details and patient eligibility

About

This study aims to evaluate the effect of intralipid infusion on reversing the spinal anesthesia effect in day case surgery.

Full description

The increasing demand for day-case surgery has led to a growing interest in developing strategies to provide patients with a more convenient, cost-effective, and less invasive alternative to traditional inpatient procedures.

Spinal anesthesia, in particular, is a widely used technique in day-case surgery due to its ability to provide excellent analgesia with minimal side effects.

Intravenous lipid emulsion therapy is commonly used to treat local anesthetic systemic toxicity (LAST) and has demonstrated some efficacy in treating other drug toxicities, particularly cardiotoxicity from lipophilic drugs.

Enrollment: 200 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age from 18 to 65 years.
• Both sexes.
• American Society of Anesthesiology (ASA) physical status I-II.
• Scheduled for day-case surgery under spinal anesthesia.
• Time of surgery less than 90 min.

Exclusion criteria

• Patients with contraindications for outpatient surgery or spinal anesthesia.
• Local anaesthetic (LA) allergy.
• Those receiving anticoagulant therapy.
• Emergency cases.
• Pregnant cases.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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200 participants in 2 patient groups

Group S

Experimental group

Description:

Patients (\>70kg will receive 100 ml, \<70 will receive 1.5ml/kg) of 20% intravenous lipid emulsion at the end of surgery as a study group.

Treatment:

Other: Lipid emulsion

Group C

No Intervention group

Description:

Patients will not receive intravenous lipid emulsion as a control group.