Does Intravenous Cannabis Reduce Postoperative Nausea and Vomiting (PONV)? (THC)

Insel Gruppe AG, University Hospital Bern

Status: Terminated

Conditions: Vomiting; Nausea

Treatments: Drug: THC 9-d-tetra hydro cannabinol

Study type: Interventional

Funder types: Other

Identifiers

NCT00695487

THC-001

KEK240_07

Details and patient eligibility

About

The investigators evaluate if intravenously applied THC (Cannabis) reduces postoperative Nausea and vomiting. THC will be given during anesthesia before emergence. We measure how long and how effective it reduces PONV

Enrollment: 320 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA I-III
• elective open and laparoscopic surgery >1hour

Exclusion criteria

• ambulatory surgery
• pregnancy, breast feeding
• >ASA III
• BMI >35
• antipsychotic, antiemetic, cytostatic therapy
• major cardiovascular, renal, hepatic, central nervous system disease
• current chronic cannabis consumption and hard drug abuse
• schizophrenia
• preoperative nausea and vomiting, vestibular disease
• not speaking german or french
• refusal to participate

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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320 participants in 2 patient groups, including a placebo group

1

Experimental group

Description:

Receives 0.125mg/kg THC before emergence

Treatment:

Drug: THC 9-d-tetra hydro cannabinol

2

Placebo Comparator group

Description:

Receives NaCl before emergence

Treatment:

Drug: THC 9-d-tetra hydro cannabinol